旅居高原肺通气功能的动态变化

DYNAMIC CHANGE OF PULMONARY VENTILATION FUNCTION AT HIGH ALTITUDE

作者在不同的海拔高度对30例健康人肺通气功能、血氧饱和度(SO_2)及流速容量曲线(MEFV)做了较长时间的动态观察。结果发现:呼吸频率(RR)、潮气量(TV)和每分通气量(MV)均随海拔升高而升高,但SO_2却随海拔升高而下降。持续海拔5000米高原11周时SO_2呈上升趋势,但MV却减少,二者呈反向变化。因此、作者认为,肺通气对缺氧的代偿是非常有限的,它需要肺血灌注和弥散功能的改善以及氧运输、氧利用的密切配合。而SO_2和MV的反向变化以及血红蛋白(Hb)的提高可能是机体在器官水平上逐渐产生了对低氧适应的结果。作者还对随海拔升高高峰流速(PEFR)的逐渐增大以及等速容量(Visov)的增大进行了讨论。

We have tested the pulmonary ventilation function oxygen saturation(SO_2) and MEFV curve dyhamically in thirty healthymen who sojourn to 4 500m and 5000m altitude for three months. We found that the RR, TV and MV were increased of altitude increasing, wheresas,the SO_2 was decreased. There were a tendency to increase SO_2 and decrease MV in eleventh week at 5000m altitude. There was a reverse change between SO_2 and MV. We thought that the compensation of pul- monary ventilation function for hypoxia is limited. Persons when acclimation to altitude the coordination of the improved lungs blood flow and gas perfusion,oxygen transport and ultilization are elso need. The reverse chang between SO_2 and MV, the increasing Hb may be as a result of acclimation for bgypoxia at organic level. The increased of PEFR with increaseing altitude and eleveted Visor in sixth week at 5000m altitude also have been discussed.