PRELIMINARY CRYSTALLOGRAPHIC STUDY ON Gly^(B30)-HUMAN INSULIN, AN ANALOGUE WITH LOW ANTIGENICITY

PRELIMINARY CRYSTALLOGRAPHIC STUDY ON Gly^(B30)-HUMAN INSULIN, AN ANALOGUE WITH LOW ANTIGENICITY

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摘要 Ⅰ. INTRODUCTIONImmune reaction remains a challenging problem in the clinical application of various insulin preparations. It is known that about 70％ of patients will produce anti-insulin antibodies after some time even if highly pure insulin is used to treat diabetes. Therefore,it is both theoretically and practically significant to understand the molecular basis of insulin immune reaction and to find new insulin preparations with low antigenicity and full bioactivity.

作者金雷伍伯牧张英王大成 R.OBERMEIER

机构地区 Institute of Biophysics Farma Forschung Biochemie

出处《Chinese Science Bulletin》 SCIE EI CAS 1992年第8期680-684,共5页

基金 Supported by a grant of UNIDO (91/048/CW)and "863" high technology program

关键词 INSULIN ANALOGUE Gly<sup>B30</sup>-human INSULIN CRYSTALLIZATION insulin analogue, Gly^(B30)-human insulin, crystallization

分类号 N [自然科学总论]

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Chinese Science Bulletin

1992年第8期

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PRELIMINARY CRYSTALLOGRAPHIC STUDY ON Gly^(B30)-HUMAN INSULIN, AN ANALOGUE WITH LOW ANTIGENICITY

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