猕猴脑动脉硬化造型过程中血清脂质的变化

The Changes Of Serum Lipids In Experimental Cerebral Arteriosclerosis

高脂高胆固醇喂养幼年(2—4岁)和成年(10—13岁)雄性猕猴16—17个月,并辅以服用甲基琉氧嘧啶。实验结果,发现第二个月的胆固醇水平超过250mg%,并持续到实验结束。低密度脂蛋白—胆固醇(LDL—C),伴随着总胆固醇升高而升高,甘油三酯(TG)和高密度脂蛋白—胆固醇(HDL—C)变化不大。幼年和成年组之间无显著性差异。

Twelve young and adult male monkeys were divided into two groups.Group Ⅰ of six monkeys was fed a labortory chow,and group Ⅱ was fed an atherogenic diet for 16—17 months.All ani- mals in group Ⅱ showed elevation of serum cholesterol levels,and over 250mg% at third month. At the end of experiment,TC and LDL—C increased significantly,but TG and HDL—C are not obvious.We also discovered that there are not much difference of serum cholesterol levels,between the young and adult monkeys.