大鼠缰核神经降压肽样,甘内肽样,P物质样和胆囊收缩素样免疫反应的老年变化

Aging Changes of Neurotensin—,Galanin—,Substance P— and Cholecystodinin—like Immunoreactivity of Habenular Nucleus in the Rat.

本文用免疫组化方法和图象分析仪观察和测量了老年大鼠和年青大鼠外侧缰核中神经降压肽(N T).甘丙肽(G AL).P物质(SP)和胆囊收缩素(C CK)免疫阳性纤维终末的分布面积和密度,老年大鼠外侧缰核中NT.GAL及CCK免疫阳性纤维终末的分布面积比年青大鼠为小,有显著(P<0.05)或非常显著差别(P<0.01),外侧缰核中GAL.SP及CCK免疫阳性纤维的密度比年青大鼠为低,有非常显著差别(P<0.01),对这种年龄变化的意义可能和记忆有关进行了讨论。

Using immunohistochemical and image analysis techniques,the distribution area and density of Neurotensin—(NT—),Galanin—(GAL—)Substance P—(SP—),Cholecystokinin(CCk)—like im- munoreactivity of lateral habenular nucleus in rat were observed and measuared.The distribution area of NT—GAL—and CCK—positive fiber terminal in lateral habenular nucleus of old rat was narked reduced as compared with the young animals.and the significantly decrease of GAL—,SP—CCK— positive fiber density in the lateral habenular nucleus was found in the old rats as compared with the young rats.The possible meaning of this changes which may be related with memory was discussed.