乳腺良、恶性病变中的肌上皮细胞变化

Myoepithelial Cell Changes in Benign and Malignant Human Breast Lesions

以偶氮荧光桃红染色显示肌上皮(myoepithelial cells,MEC),并与超微结构对比观察。分析76例乳腺良、恶性病变MEC存在、分布方式同形态变化规律。结果表明:除粘液癌外,各型乳腺癌均存在MEC,导管浸润癌中存在大量瘤性MEC,MEC可能积极参与乳腺癌的形成,也有恶变之可能,与文献报导不同;偶氮荧光桃红特染联合超微结构观察对判断乳腺增生症早期恶变倾向,原位癌早期浸润有一定意义。

The article has investigated the presence, distribution and morphological changing law of myoepithelial cells in 76 cases with benign and malignant human breast lesions, using azophloxin-staining with ltiastructural observation The results indicated that every pattern of breast carcinomas, except mucous carcinoma, contained myoepithelium. There were a large numberof neoplslsatic myoepithelial cells in the infiltrating ductal carcinoma; myoepithelial cel, not only may actively taken part in the formation of mammary carcinomas but also had a possibility of malignancy, which were not similar to repotedrureferences. The characteristic azophloxin-staining to myoepithelium in associaion with ultrastractural observations may were significant to defect the early malignant tendency of hyperplastic mastopathy as well as early infiltration fobreast carcinoma in situ.