海人酸毁损纹状体后大鼠例脑室注射吗啡对黑质神经元单位放电的影响

THF EFFECTS OF LATERAL VENTRICULAR INJECTION OF MORPHINE ON THE SPONTANEOUS FIRING OF NEURNS IN THE RAT SBSTANTIA NIGRA AFTER THE STRIATUM WAS LESTONED BY KANC ACID

本实验用单管微电极的方法,共记录了63个黑质(SN)神经元的自发放电。其中观察了45个黑质神经元,在用海人酸(KA)毁损同侧纹状体后,对侧脑室注射吗啡(MOR)的反应,18个黑质神经元,在同侧纹状体内注射配药液后,对侧脑室注射吗啡的反应。结果表明:海人酸毁损纹状体后可阻断吗啡对黑质Ⅰ型神经元的作用但不影响吗啡对黑质Ⅱ型神经元的作用。

The spontaneous firing of 63 nigra neurons was recorded by the single barrel glassmicropipette in rat. The effects of lateral ventricular injection of morphine (MOR) on ipsilateral nigral neurons (n=45) were observed after the striatum was lesioned by kainic acid. The vehiele was imjeeted to the striatum insteaed of kainie aeid lesion in control group (n=18). The results of study have demonstrated that after the striatum was lesioned by kainic aeid, the effeets of morphine on type Ⅰ neurons in the substantia nigra were blocked, but the effects of morphine on type Ⅱ neurons were not influeneed.