摘要
Artificial cerebrospinal fluid （c.s.f.） containing 40 mmol/L excess calcium was perfus-ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na<sup>+</sup>/Ca<sup>++</sup> ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-nophosphate （cAMP） concentration in plasma and c.s.f, during leucocytic pyrogen （LP）-induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,while there appears no effect on plasma cAMP concentration, thus demonstrating that theincrease of Na<sup>+</sup>/Ca<sup>++</sup> ratio causing the increase of cAMP content in the brain may be anessential link in the pathogenesis of LP-induced fever.
Artificial cerebrospinal fluid (c.s.f.) containing 40 mmol/L excess calcium was perfus-
ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na^+/
Ca^(++) ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-
nophosphate (cAMP) concentration in plasma and c.s.f, during leucocytic pyrogen (LP)-
induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-
ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-
ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-
icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,
while there appears no effect on plasma cAMP concentration, thus demonstrating that the
increase of Na^+/Ca^(++) ratio causing the increase of cAMP content in the brain may be an
essential link in the pathogenesis of LP-induced fever.
