摘要
Artificial cerebrospinal fluid (c.s.f.) containing 40 mmol/L excess calcium was perfus-ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na^+/Ca^(++) ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-nophosphate (cAMP) concentration in plasma and c.s.f, during leucocytic pyrogen (LP)-induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,while there appears no effect on plasma cAMP concentration, thus demonstrating that theincrease of Na^+/Ca^(++) ratio causing the increase of cAMP content in the brain may be anessential link in the pathogenesis of LP-induced fever.
Artificial cerebrospinal fluid （c.s.f.） containing 40 mmol/L excess calcium was perfus-ed through the lateral ventricles of New Zealand white rabbits in order to reduce the Na<sup>+</sup>/Ca<sup>++</sup> ratio in the brain and the effects on both the febrile response and adenosine cyclic mo-nophosphate （cAMP） concentration in plasma and c.s.f, during leucocytic pyrogen （LP）-induced fever were observed. The results showed that cAMP concentration in c.s.f, increas-ed significantly during LP-induced fever while the cAMP level in Plasma remained unchang-ed, and the perfusion of artificial c.s,f, containing 40 mmol/L excess calcium can signif-icantly inhibit not only the febrile response but also the increase in c.s.f, cAMP level,while there appears no effect on plasma cAMP concentration, thus demonstrating that theincrease of Na<sup>+</sup>/Ca<sup>++</sup> ratio causing the increase of cAMP content in the brain may be anessential link in the pathogenesis of LP-induced fever.
