高脂饲料和鸦胆子油对长爪沙鼠血清脂类的影响

Effect of High Lipid Diet and Brucea Javanica Oil on Serum Lipid in Mongolian Gerbil

本实验首次经酶学方法观察给予高脂肪、高胆固醇饲料和鸦胆子油的长爪沙鼠血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及其亚组分与甘油三酯含量变化。结果提示高脂饲料影响沙鼠血脂成份明显,易形成高脂血症,鸦胆子油有一定程度的降血脂作用。

Serum lipid,lipoprotein and HDL-c subfractions of Mongolian gerbil were compared by enzymatic method among three different groups. One group fed high lipid diet, the second group fed high lipid diet plus Brucea javanica oil ( rich in unsaturated fat acid ) , and the third group fed basic forage as control. Compared with the control group, the high lipid diet group showed hyperlipemia. The elevation of gerbil's serum cholesterol was asso-ciated with that of LDL-c and HDL-c. The latter contained HDL2-c and HDL3-c. Serum triglyceride was also elevated. The Brucea javanica oil group showed reduced hyperlipemia, compared with the high lipid diet group The reduction of gerbil's serum cholesterol may be caused by the lowering of the cholesterol content in LDL-c and HDL-c. Serum triglyceride was also lowered. The effect is of benefit to antiatherosclerogenesis.