摘要
Fifty-seven severely burned patients were divided into 2 groups:16 withmultiple organ failure（MOF）,and 41 without MOF.It was found that the levelof thromboxane B<sub>2</sub>（TXB<sub>2</sub>）and the ratio between TXB<sub>2</sub> and 6-keto-prostaglandinF<sub>1α</sub>(TBX<sub>2</sub>/6-keto-PGF<sub>1α</sub>)in plasma and in visceral tissues were increased and re-mained significantly high in the first 5～7 d postburn in patients with MOF but notso in those without MOF.The circulatory platelet aggregate ratio（CPAR）wasmarkedly decreased in the same period in MOF group.Myocardial enzymes（CPK,LDH,and GOT）were markedly increased in the first 3d and remainedsignificantly high within 7 d postburn.Degeneration,structural destruction,edema,hemorrhage and thrombosis were revealed in cardiac,pulmonary,renal andhepatic tissues succumbing to functional failure.Thirteen out of the 16 cases de-veloped MOF during the 3rd to 7th day posthurn and 11 died in that period.These findings substantiate that persistent increase of thromboxane andthromboxane/prostacyclin ratio is closely related to the origin and development ofMOF after burn injury.
Fifty-seven severely burned patients were divided into 2 groups:16 with multiple organ failure(MOF),and 41 without MOF.It was found that the level of thromboxane B_2(TXB_2)and the ratio between TXB_2 and 6-keto-prostaglandin F_(1α)(TBX_2/6-keto-PGF_(1α))in plasma and in visceral tissues were increased and re- mained significantly high in the first 5～7 d postburn in patients with MOF but not so in those without MOF.The circulatory platelet aggregate ratio(CPAR)was markedly decreased in the same period in MOF group.Myocardial enzymes(CPK, LDH,and GOT)were markedly increased in the first 3d and remained significantly high within 7 d postburn.Degeneration,structural destruction,edema, hemorrhage and thrombosis were revealed in cardiac,pulmonary,renal and hepatic tissues succumbing to functional failure.Thirteen out of the 16 cases de- veloped MOF during the 3rd to 7th day posthurn and 11 died in that period. These findings substantiate that persistent increase of thromboxane and thromboxane/prostacyclin ratio is closely related to the origin and development of MOF after burn injury.
