摘要
The effects of somatostatin and cysteamine injected into theventromedial nucleus of hypothalamus(VMH)on somatostatin-likeimmunoreactivity(SLI)concentration in the gastric antral mucosa and portal veinplasma,as well as the gastric acid secretion were studied in anesthetized rats.TheSLI concentration in the gastric antral mucosa and portal vein plasma and thegastric acid output were significantly increased one hour after the injection ofsomatostatin(0.5μg/0.5μ1)into the VMH.Four hours later,the SLI concentrationin the mucosa was still higher than the control level,while the SLI level in theplasma and the acid secretion were close to those of controls.On the contrary,the SLI concentration in the mucosa and plasma and the acid output weremarkedly decreased at four hours after the injection of cysteamine(15μg/0.5μ1)into the VMH.The present results suggest that both exogenous and endogenoussomatostatin in the VMH have a facilitatory action on the gastric somatostatinconcentration and its release as well as on the gastric acid secretion,thus provid-ing evidence for hypothalamic control of gastric somatostatin and acid secretion.
The effects of somatostatin and cysteamine injected into the ventromedial nucleus of hypothalamus(VMH)on somatostatin-like immunoreactivity(SLI)concentration in the gastric antral mucosa and portal vein plasma,as well as the gastric acid secretion were studied in anesthetized rats.The SLI concentration in the gastric antral mucosa and portal vein plasma and the gastric acid output were significantly increased one hour after the injection of somatostatin(0.5μg/0.5μ1)into the VMH.Four hours later,the SLI concentration in the mucosa was still higher than the control level,while the SLI level in the plasma and the acid secretion were close to those of controls.On the contrary, the SLI concentration in the mucosa and plasma and the acid output were markedly decreased at four hours after the injection of cysteamine(15μg/0.5μ1) into the VMH.The present results suggest that both exogenous and endogenous somatostatin in the VMH have a facilitatory action on the gastric somatostatin concentration and its release as well as on the gastric acid secretion,thus provid- ing evidence for hypothalamic control of gastric somatostatin and acid secretion.
