失代偿期肝硬化蛇毒凝血像与传统肝功能指标的评价

Comparitive Study of Venon Reagent Coagulation and Traditional Hepar Function Tests

以中国蝰蛇毒试剂及中国蕲蛇毒试剂检验了60例失代偿期肝硬化病人的蛇毒凝血像(蝰蛇毒磷脂时间-RVVCT;靳蛇毒时间-AT;蝰蛇毒血小板因子3活性测定-RVVPF3aT),并与常规肝功能指标进行了对比,证明蛇毒凝血试验结果显著高于正常对照组(P<0.001);异常检出率亦明显高于传统凝血试验及大部常规肝功能检查结果(P<0.0001)并与慢性指标成正相关;而且随着肝功Child分级的加重血液凝固时间愈长(P<0.05)。提示蛇毒凝血试验为一较好的探测肝脏损害、凝血障碍、肝脏储备功能的新试验,值得推广。

We used Chinese russell's Viper Venon Reagent (CAAVR) and Chinese Agkistrodon Acutus Venon Reagent (CAAVR) to examine 60 patients with decompensation cirrhosis for their venon reagent coagulation tests, which include Agkistrodon Acutus Venon Time (AT), Russell's Viper Venon Cephalin Time (RCT) and Russell's Viper PF3a Time (PF3aT). And we also compared them with regular hepatic function tests. It was verfied that the conclusion of venon reagent coagulation tests was much higher than that of the comparable group (P<0.0001), and the abnormal rate was much higher than that of traditional coagulation tests and regular hepatic function tests (P< 0.0001). The more severe hepatic disfunction for Child Grade, the longer the coagulation time (P< 0.05). It is suggested that venon reagent coagulation tests is a new better method of examination of hepar disfunction, coagulation abnormality and hepar reserved function. It is worth recommending.