颅内压监护:甘露醇疗效分析

ICP Monitoring: Analysis of the Efficacy of Mannitol Application

用持续ICP(颅内压)监护方法分析以每6小时静注一个剂量20%甘露醉对降低颅内压的疗效。共对23例进行158次治疗。发现有效率只占55.7%,而使用甘露醇后ICP继续上升或出现反跳现象者占34.8%。当ICP在4～45mmHg时,甘露醇的治疗有效率随使用前ICP的增高而上升,且随使用次数的增多而降低.在ICP监护下,ICP达25mmHg时使用甘露醇治疗效果良好。

The method of continuously monitoring intracranial pressure (ICP) was used to observe the efficacy of mannitol application to reduce ICP by a dose of 20% mannitol infusion every 5 hours. The efficacy rate of 158 treatments in 23 patients was only 55. 7% and ICPs were not reduced but elevated continuously or rebounded after mannitol administration in 34. 8%. Mannitol was less effective in the following conditions: l,ICP<20mmHg(2. 67KPa); 2,repeated treatments for many times; 3,patients with extensive brain injury. Mannitol was more effective when ICP was over 25mmHg(3. 33KPa)and the treatment could be considered when ICP was over 20mmHg(2. 67Kpa). Mannitol may be useless or even harmful without ICP monitoring. The reasonable application of mannitol should be under the monitoring of ICP.