益气养阴活血治法的抗衰老机理研究IV.气血通抗血栓、改善微循环及抗脂质过氧化作用研究

Studies of Qi xue Tong on Antithrombosis, Improving the Microcirculation and Resisting to the Lipid Peroxidation in Rats

以老年雄性大鼠做为老年血於模型,将气血通冲剂给老年大鼠灌胃,结果可见在体血栓形成时间延长,而离体血栓长度缩短,血小板一分钟聚集率和最大聚集率皆明显降低。RBC滤过指数(IF)也降低,此外,心、肝、脑组织中之MDA含量也明显下降,表明气血通对老年大鼠有明显的抗血栓形成、抑制血小板聚集、改善RBC变形能力和抗脂质过氧化作用。

The old male rats are used as the blood stasis model. 'Qi Xue Tong' ,which has the effects of tonifying Qi, nourishing Yin and removing blood stasis of the elderly and employs to treat the senile diseases (such as coronary heart disease, cerebral thrombosis etc.), is treated to the old rats with os for 14 days. The results show that the obstructive time of thrombosis in vivo is prolonged (compared with old control group P< 0.001), while the length of thrombosis in vitro is reduced (P<0,05).The platelet aggregation one minute rate and maxium rate are markedly decreased (P<0.01 and P< 0.001). The RBC Filtration Index also decreased (P<0.001) . Beside these, the MDA content in myocardium, liver and brain tissues are also remarkably declined (P<0.001, P<0.01, P<0.001)