复方胃乃安的药理学研究——二、作用机制的初步探讨

Pharmacological Studies on Patent Chinese Drug Wei Nai An(W.N.A.)——Ⅱ.Preliminary studies on the Mechanisms of Action of W.N.A.

胃乃安水煎剂灌胃给药可明显降低幽门结扎大鼠游离酸和总酸的含量,但对胃液分泌量,胃蛋白酶排出量及胃壁粘液的含量没有明显影响。胃乃安水煎剂可使离体大鼠胃底条及豚鼠回肠平滑肌收缩,并呈明显的量效关系。虽然胃乃安具有直接中和胃酸的作用,但其主要抗溃疡机制可能是通过中枢神经系统的影响,从而起到抗溃疡作用。

The mechanism of action of W.N.A. in preventing gastric ulcers was studied. An analysis of gastric contents in pylorus-ligated rat indicated a decreased free and total acidity as a result of W.N.A. treatment. In contrast, W.N.A. exerted little influenc on gastric volume, acid output and pepsin output. Results also showed that W.N.A. (上接第10页) has no effect on the amount of mucus in gastric contents or bound to the mucosa. Decoction cf W.N.A. cbviously induced contractile response of isolated guinea pig ileum and rat fundus strip. The mechanism of action of Huang Qi (HQ) may be partly through activizing cholinergic M-receper, since the contractile action of H.Q. can be partly blocked by atropine. These obseervations suggested that the mechanism of action of W.N.A. is likely to occur by influencing the activity of central nervous system and neutralizing gastric acid directly. How-ever, it seems that farther studies may.be need to identify whether or not through other unknown anti-ulcer channel.