氯化镁局部导入对鼻咽癌颈淋巴结转移癌的放射增敏效应

RADIOSENSITIZATION BY LOCAL IONOPHORESIS OF MgCl_2 INTO THE METASTATIG CERVICAL LYMPH NODE OF NASOPHARYNGEAL CARCINOMA

为寻找新的放射增敏剂及给药途径,我科曾利用放射加卤碱阳极离子导入治疗颈部转移癌,已取得较好的疗效。在动物实验中证实,卤碱放射增敏作用的有效成份为氯化镁。本文选择鼻咽癌颈淋巴结转移癌为研究对象,进行放射加氯化镁局部导入和单纯放射的对照研究,现将其近期临床疗效报道如下。

Thirty patients with cervical lymph node metastasis from nasopharyngeal carcinoma were randomly divided into two groups. 1. Group A, radiotherapy plus local ionophoresis of MgCl2. 2. Group B, radiotherapy alone. The rates of complete response of cervical metastasis of Group A (73.3%) in comparison to that (46.7%) of Group B were significantly different. The time required for CR in Group A (15.7 days) was also shorter than that of Group B (22.1 days). The dose of 25% and 50% volume reduction in Group A(g.44Gy and 16.5 Gy)were also significantly lower than those in Group B (15.12 Gy and 26.5Gy)f