摘要
全身预先照射对肿瘤人工血行转移的影响与照射剂量,肿瘤免疫原性等诸多因素有关。已报道的文献矛盾之处颇多。本实验主要研究不同照射剂量对B<sub>16</sub>黑色素瘤人工血行转移的影响,对其中大剂量照射组观察了小鼠脾脏NK细胞体外细胞毒活性及脾脏淋巴细胞转化率的影响,并以小鼠肺对<sup>125</sup>IudR标记的B<sup>16</sup>黑色素瘤的消除率为指标检测了体内NK活性。
The effect of one single dose whole-body irradiation on the pulmonary metastasis of B16 melanoma in C57BL/6 mice as related to the immunologic changes was investigeted. The results showed that at dose 0.5-6 Gy, the number of metastatic nodules was increased exponentially with the increase of dose which might be related to the supression of NK or/and T cells.
出处
《中华放射肿瘤学杂志》
CSCD
1991年第1期38-40,共3页
Chinese Journal of Radiation Oncology
