鼻咽癌放疗剂量的评价——附180例分析

EVALAUATION OF DOSE IN THE TREATMENT OF NASOPHARYNGEAL CARCINOMA (NPC)——Analysis of 180 patients

鼻咽癌放射治疗(放疗)对肿瘤靶区给与多少剂量为佳有不少作者进行过研究,意见不尽一致。为此对我科从1977～1986年收治的180例单纯放疗鼻咽癌病例作回顾性分析,以探讨肿瘤剂量对预后的影响以及肿瘤消退情况与放射量的相关性。

180 patients with NPC were treated from 1977-1986. The 3- and 5- year survival rates were 64% and 55%. There was no significant difference in the survival rates of different dose groups. When the primary lesion disappeared <60 Gy, those patients with radiation therapy concluded and those who received further local boosts gave similar recurrence rates. In patients whose primary lesion disappeared grossly at 70-75 Gy/7-7.5 wk, local boosts did not improve the surviual rate. Instead, it increased the complication. For lymph node metastasis which disappeared <60 Gy, a local boost of 15-30 Gy was not any better than 10-15 Gy.The optimum dose for cervical lymph node metastasis was 60-70 Gy. The authors believe that too high a local dose is not warranted. Strict follow-up at 2-3 month intervals is advised. Recurrence developed should he operated.