摘要
The level of lipid peroxides (LPO) and copper-zinc containing superoxide dismutase (SOD-Ⅰ) in the gastric mucosa and serum was determined in 141 samples from 25 patients after con-ventional subtotal gastrectomy (11 cases of Billroth Ⅰ and 14 cases of Billroth Ⅱ) and 11 patientsafter pylorus and antroseromuscular flap preserving gastrectomy (PAFPG).Those of 11 normal subjects were examined likewise to serve as control.It was found that:(1) The average LPO levelwas much higher and the average SOD-Ⅰ level much lower in the gastric mucosa of the patientsafter conventional subtotal gastrectomy especially the Billroth Ⅱ type than in that of those afterPAFPG.(2) In 36 specimens of stump mucosa,the average LPO level was significantly higher inthe tissue around the anastomotic ring than in that of the body of the stump;no marked differ-ence of SOD-Ⅰ level between the 2 was revealed.(3) The LPO value in the stump mucosa waspositively correlated to and the SOD-Ⅰ value negatively correlated to the pH value of gastric juice.These rindings suggest that the reation of oxygen free radicals in the stump mucosa may be influ-enced by the intragastric pH or by the type of digestive continuity reconstruction,and that thereaction of oxygen free radicals especially the lipid peroxidation may play a role in the pathogenesisof the lesions in the anastomotic stoma.
The level of lipid peroxides (LPO) and copper-zinc containing superoxide dismutase (SOD- Ⅰ) in the gastric mucosa and serum was determined in 141 samples from 25 patients after con- ventional subtotal gastrectomy (11 cases of Billroth Ⅰ and 14 cases of Billroth Ⅱ) and 11 patients after pylorus and antroseromuscular flap preserving gastrectomy (PAFPG).Those of 11 normal sub jects were examined likewise to serve as control.It was found that:(1) The average LPO level was much higher and the average SOD-Ⅰ level much lower in the gastric mucosa of the patients after conventional subtotal gastrectomy especially the Billroth Ⅱ type than in that of those after PAFPG.(2) In 36 specimens of stump mucosa,the average LPO level was significantly higher in the tissue around the anastomotic ring than in that of the body of the stump;no marked differ- ence of SOD-Ⅰ level between the 2 was revealed.(3) The LPO value in the stump mucosa was positively correlated to and the SOD-Ⅰ value negatively correlated to the pH value of gastric juice. These rindings suggest that the reation of oxygen free radicals in the stump mucosa may be influ- enced by the intragastric pH or by the type of digestive continuity reconstruction,and that the reaction of oxygen free radicals especially the lipid peroxidation may play a role in the pathogenesis of the lesions in the anastomotic stoma.
