摘要
Taxol was used as a tool reagent and the function of the microtubules (MTs) beneath thepostsynaptic membrane was studied in an isolated non-uniformly stretched muscle preparation of ratdiaphragm.After exposure to taxol (20 μmol/L,10min),the amplitude of acetylcholine potential ofinnervated muscle endplate was decreased by 30%,but the lime course of AChP and membrane po-tential remained unchanged.The results indicate that taxol can inhibit the responsiveness ofpostsynapfic membrane.It is therefore suggested that the site of action of taxol indudng inhibitionof postsynapfic responsiveness in neuromuscular junction may be the microtubules beneath thepostsynapfic membrane.
Taxol was used as a tool reagent and the function of the microtubules (MTs) beneath the postsynaptic membrane was studied in an isolated non-uniformly stretched muscle preparation of rat diaphragm.After exposure to taxol (20 μmol/L,10min),the amplitude of acetylcholine potential of innervated muscle endplate was decreased by 30%,but the lime course of AChP and membrane po- tential remained unchanged.The results indicate that taxol can inhibit the responsiveness of postsynapfic membrane.It is therefore suggested that the site of action of taxol indudng inhibition of postsynapfic responsiveness in neuromuscular junction may be the microtubules beneath the postsynapfic membrane.
