致痫病灶神经递质类氨基酸的变化

Amino acid analyses in epileptogenic foci

本文比较了10份手术切得的致痫病灶和7份非癫痫患者相应部位的皮层组织的5种游离神经递质类氨基酸含量。发现病灶中 Gly 显著升高(P<0.01),同时 Glu 和 Asp电有较显著升高(P<0.05);而 Tau 和 GABA 虽略低于对照组,但无统计学差异。因此,本实验结果为兴奋性神经递质增高,可能为致痫因素这一观点提供了证据,同时也提示病灶组织内氨基酸的含量与服用抗痫药物有关。

Amino acid contents of 10 epileptogenic loci removed surgically from temporal cortex oF 10 patients with focal epilepsy were compared with those samples taken from the same cortical regions of 7 nonepileptic patients.Taurine and GABA contents were slighly reduced in epileptogenic loci.Glycine level was elevated markedly in some foci. Mear glutamic acid and aspartic acid contents were significantly higher in epileptogenic foci than in control cortex.Our findings suggest a possible etiologic role for the exci1tory neurotransmitters,Glu and Asp.The results also show a relation between changes of amino acid contents and regimes of anticonvulsant drugs.