保肾丸治疗长期血液透析患者的临床研究

Effects of rheum on treating chronic renal failure with maintenance hemodialysis

本文应用口服大黄提取物制成的保肾丸治疗22例维持性血液透析(血透)患者,考察大黄对慢性肾衰的作用.平均治疗时间为5.3±1.2个月。治疗后 BUN 和 Scr 水平无明显变化,与非治疗组相比亦无明显差异.但治疗后血清 HDL-Ch,apoA_1、血清白蛋白、前白蛋白和纤维连接蛋白均明显增加,血清 TG,LDL-Ch,apoB 和 apoB/apoA_1明显降低,而非治疗组无明显变化.表明大黄治疗终末期肾衰的血透患者对 BUN 和Scr 并无明显变化,而具有明显的降血脂和调节脂蛋白与载脂蛋白,提高血浆蛋白水平的功能,可能在肾哀治疗中起着一个很重要的作用.

A clinical trial,to evaluate the effcts of a Chinese herb drug,Rheum on hemodialysis(HD) patients was conducted.Fortytwo cases with End Stage Renal Failure(ESRF,Cer Sml/min) on HD were divided at random into two groups:Rheum treated group and the control group.All the patients were treated with regular hemodialysis under similar regiem du- ring the 5.2±1.2 months. The results showed there were no significant differences the BUN and the Set levels.Serum levels of TC,TG,LDL-c,apo B and apo B/apo A,ratio fell down with a concomitant rising of HDL-c,apo A_1,albumin,prealbumin and fibrinectin during the follow-up period of treated patients. Rheum exerts beneficial effect on lipids and protien metabolism of ESRF patients maintained on hemodialysis just like those not receiving dialysis treat- ment which might be an important mechanism in preventing progression of CRF.