麦迪霉素胶囊的生物利用度和药动学研究

The bioavailability and pharmacokinetics of medecamycin capsuls

本文用反相快速柱测定血清中麦迪霉素浓度.对12例健康受试者自身交叉口服600mg 日本和国产的麦迪霉素胶囊后测定其血药浓度,计算药代动力学参数和相对生物利用度.麦迪霉素口服吸收表现为一房室模型。其药动学参数,日本和国产的分别为 t 1/277.3±28.3min,76.2±26.9min;Ka 0.2260±0.27601/min,0.1476±0.1919 1/min:tpk89.2±50.2min,93.8±40.6min;Cpk0.20±0.09mg/L,0.18±0.07mg/L。相对生物利用度(F 校正)为1.00±0.25。

In this study a reversed-phase speed-column was used to de- terminate the serum medecamycin concentration.600mg of medecamycin from Japan and China was orally administrated to 12 healthy volunteers alternati- vely in a random sequence.After the serum concentrations in different time were determiuated with a reversed-phase speed-column,the pharmacokinetic parameters and the relative bioavailability were calculated,respectively.The parameters of the Japanese and Chinese madecamycin capsuls products were as follows:t(1/2) 77.3±28.3,76.2±26.9min;Ka 0.2260±0.2760,0.1476±0.1919 min^(-1);Tpk 92.8±50.9,100.6±41.4min;Cpk 0.20±0.09,0.18±0.08mg/L. The relative bioavailability (F correction) was 1.00±0.25.