高原红细胞增多症及高原居民环核苷酸变化的初步探讨

THE PRELIMINARY STUDY ONTHE CHANGE OF CYCLONUCLEOTLDES IN THE PATLENTS WITH HIGH ALTITUDE POLYCYTHEMIA(HAPC) AND THE HIGH ALTITUDE RESIDENTS

本文以放射免疫法检测了HAPC患者、海拔3 460m地区居民以及作为对照的苏州地区人群的CAMP与CGMP血浆含量、结果发现;(1)CAMP随海拔高度上升、缺氧加重,而逐步下降;CAMP/CGMP比值,HAPC患者<海拔3 460m居民<平原地区居民;(2)HAPC患者急进平原后,以CAMP迅速上升为主,CAMP/CGMP比值增加1倍以上;(3)CAMP/CGMP比值与Hb、PCV呈明显负相关。提示:(1)高原低氧是产生CAMP减少和CAMP/CGMP比值下降的重要因素;(2)环核苷酸的变化始终有效地调拉着红细胞的消长和参与HAPC的发病机理。

The plasma contents of cAMP and cGMP were measured with radioimmunoassay in the patients with HAPC and the healthy high altitude (3 460m)subjects,and in the lowland (Suzhou area)subjects who served as controls. The results revealed that (1)cAMP gradually declined with the asent of sea-level and the increasing severity of hypoxia ;the ratio of cAMP/cGMP augmented in turn, from HAPC patients, highland subjects to lowland subkects; (2)after HAPC patients actully arriving at lowland,the promptlve increase in cAMP was pre- dominant, the ratio of cAMP/cGMP increased by a more than a time.(3)An obvious inverse association between ratio of cAMP/cGMP and Hb,PCV was revealed, These phenamena suggested that (1)the high altitude hypoxia is the important cause for cAMP decreasing and the ratio of cAMP/cGMP declining; (2)the change of erythro- cytr from begining to end, and relates with the formation of HAPC.