平阳霉素对头颈部鳞癌选择性治疗作用的临床病理研究

CLINICOPATHOLOGICAL STUDY OF THE SELECTIVE THERAPEUTIC EFFECT OF PINGYANGMYCIN ON SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

本文对12例三、四期头颈部鳞癌单一用国产平阳霉素作术前化疗进行详细临床观察,并以光镜和电镜作病理观察。发现平阳霉素对头颈部鳞癌具有疗效显著副作用轻微的优点。并发现药物疗效与肿瘤的部位、大小及临床类型有关。溃疡型较隆起型对药物敏感性强,但易于复发,应于化疗后及时进行手术或放疗。病理研究发现平阳霉素的作用机制,主要是促进癌细胞的角质化变性,同时影响了癌细胞的代谢功能,进而导致癌细胞坏死、由于该药选择性地作用于鳞癌,同时还有增强宿主免疫力的功能,从而使其具备了疗效显著对人身副作用轻微的优点。

12 cases of 3 and 4 stage squamous cell carcinoma of the head and neck only treated with pingyangmycin (PYM) preoperatively were studied by detailed clinical observation and pathological observation with optical and electron microscope. It has been found that PYM had the most effective on squamous cell carcinoma of the head and neck and mild side effects.the curative effect may be concerned with site, size and clinical type of tumor.The ulcerous type is more sensitive to the medicine than the protruded type but more easing recurs.So the patients must be operated or be treated with radiation in time after chemotherapy. It has been found by pathologic study the actions principle of PYM is mainly due to the ability of promoting keratinazation and deterioration, affecting the cancer cell's function of metabolism and leading to the cancer cell's necrosis. Because PYM selectively acts on squamous cell carcinoma and promotes the immunity, it has the advantage of the most effective and mild side effects.