玉米油对2型糖尿病大鼠胰岛素抵抗的作用研究

The role of corn oil in type 2 diabetes rats with insulin resistance

目的研究玉米油对2型糖尿病大鼠胰岛素抵抗的血糖、血脂以及胰岛素的影响,并初步研究其作用机制。方法以高脂高糖饲料及小剂量链脲佐菌素(streptozotocin,STZ)建立2型糖尿病胰岛素抵抗大鼠模型。将32只SD大鼠随机分为正常对照组,糖尿病模型组,玉米油(0.8 mg/kg)组,罗格列酮组(阳性对照组)。连续灌胃6周,测定空腹血糖(fasting blood glucose,FBG)、总胆固醇(total cholesterol,TC)水平、甘油三酯(triglyceride,TG)、低密度脂蛋白(low densitylipoprotein,LDL)、高密度脂蛋白(high density lipoprotein,HDL)、空腹胰岛素(fasting insulin,FINS),并计算胰岛素抵抗指数(HOMA—estimated insulin resistance,HOMA-IR)。结果玉米油可升高糖尿病大鼠HDL的含量,降低FBG、TC、TG、LDH、FINS及HOMA-IR(P<0.05)。结论玉米油对2型糖尿病大鼠有改善胰岛素抵抗、降低血糖血脂的作用。

Objective To study the role of corn oil in the change of serum glucose, serum lipids and insulin in type 2 diabetes rats with insulin resistance, and attempt to find out its mechanism. Method High fat and sugar diet plus low-dose streptozotocin (STZ) was given to establish type 2 diabetes rat with insulin resistance model, the rats of which were randomly divided into normal group, model group, corn oil (0.8 mg/kg) group, rosiglitazone group. After Ig 6 weeks, fasting blood glucose (FBG), total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), high density lipoprotein (HDL), fasting insulin (FINS), and insulin resistance index (HOMA-IR) were detected. Results Corn oil can elevate the level of HDL in diabetic rat, lower the levels of FBG, TC, TG, LDL, FINS and HOMA-IR. Conclusion Corn oil can improve insulin resistance, and decrease the serum glucose and lipid of type 2 diabetic rats.