中药补肾调周法对肾阳虚型多囊卵巢综合征患者血清瘦素的影响

Effect of Tonifying Kidney with Traditional Chinese Medicine on Serum Leptin Levels in Patients with Polycystic Ovarian Syndrome

目的探讨石英毓麟汤补肾调周法配合戊酸雌二醇片和氯菧酚胺治疗多囊卵巢综合征(polycystic ovarian syndrome,PCOS)的疗效及对患者血清瘦素的影响。方法 208例PCOS患者随机分为观察组104例和对照组104例。对照组服用雌二醇片和氯菧酚胺,观察组在对照组的基础上加服石英毓麟汤补,累计3个周期;对患者的多毛,测定基础体温,座疮和月经异常情况进行了记录;采用酶联免疫法检测血清瘦素(Ieptin,LP)和促卵泡生成激素(follicle stimulating hormone,FSH),促黄体生成激素(luteinizing hormone,LH),泌乳素(prolactin,PRL),雌二醇(estradiol,E_2),睾酮(testosterone,T)五种内分泌激素含量。结果采用西药和中药补肾调周法治疗后的患者月经异常、痤疮、多毛、单相测定基础体温情况比治疗前明显改善;两组患者的FSH,LH,PRL,E_2,T均有所降低,而观察组患者的FSH和PRL均高于对照组,LH,T和E_2水平均低于对照组。结论中药补肾调周法治疗PCOS能显著降低FSH,LH,PRL,E_2。T和LP水平。相较于单纯使用西药,中药补肾调周法优于单纯使用西药治疗。

Objective To explore the effect of tonifying kidney with traditional Chinese medicine together with estradiol valerate and clomiphene citrate on serum leptin levels in patients with polycystic ovarian syndrome. Method Two hundred and eight patients with PCOS were randomly divided into observation group (n=104) and control group (n=104). Patients in control group and observation group took estradiol valerate and clomiphene citrate, while patients in observation group took Shiying Minlin soup for three months. Crinosity, body temperature, acne&Skin diseases, and menoxenia were recorded; Leptin (LP) and five hormone including follicle stimulating hormone (FSH),luteinizing hormone (LH), prolactin (PRL), estradiol (E 2) and testosterone (T) are determined using euzymelinked immunosorbent assay. Results Crinosity, body temperature, acne&Skin diseases, and menoxenia were improved;the level of FSH, LH, PRL, E 2, T in both observation and control group decreased and the content in observation group are high than that in control group, while LH,T and E 2 are lower. Conclusion Treatment with tonifying kidney with traditional Chinese medicine on polycystic ovarian syndrome can decrease the level of FSH, LH, PRL, E 2, T and LP. Compared with western medicine, tonifying kidney with traditional Chinese medicine showed advantage in the terms of treatment on polycystic ovarian syndrome.