三种黄体酮治疗功能性子宫出血的临床效果及药物经济学评价

Cost-effectiveness analysis of three types of progesterone dosage forms in treatment of functional uterine bleeding

目的评价黄体酮的3种剂型治疗功能性子宫出血的临床疗效和安全性,并用药物经济学方法研究3种治疗方案的成本-效果。方法将180例功能性子宫出血患者随机分为A、B、C组(n=60),在口服戊酸雌二醇的基础上,分别给予黄体酮胶囊、黄体酮栓、黄体酮阴道凝胶,观察3组的临床疗效,并进行成本-效果分析。结果 A、B、C组的总有效率分别为71.67%、86.67%、93.33%,不良反应发生率分别为5.00%、3.33%、6.67%,成本-效果比分别为336.26、98.80、1501.60,A组、C组相对于B组的增量成本-效果分别为-1035.80、19751.57。结论黄体酮栓(B组)治疗功能性子宫出血效果最佳,经济学指标最好。

Objective To explore the efficacy and safety of three types of progesterone dosage forms in treatment of functional uterine bleeding, and compare their cost-effectiveness. Methods 180 cases with functional uterine bleeding were radomly divided into A,B,C three groups,each had 60 cases. On the basis of oral estradiol valerate,A,B and C group were given progesterone capsules,progesterone suppository and progesterone vaginal gel, respectively. The efficacy and cost-effectiveness were observed and compared. Results The efficacy rate of A,B and C group were 71.67%,86.67%and 93.33%,respectively. The adverse reaction ratio of A,B and C group were 5.00%,3.33% and 6.67%,respectively. The cost-effectiveness ratios were 336.26,98.80 and 1501.60,respectively. The increment of cost-effectiveness of A group and C group were-1035.80 and 19751.57.Conclusion Progesterone suppository(B group)has best effect in treatment of functional uterine bleeding.