益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的疗效及安全性分析

Efficacy and safety of probiotics combined with kangfuxin solution in treatment of mild and moderate active ulcerative colitis

目的探讨益生菌联合康复新液对活动期轻中度溃疡性结肠炎的疗效及安全性。方法选取南阳市中心医院80例活动期轻中度溃疡性结肠炎(ulcerative colitis,UC)患者,按入院顺序平均分为2组,对照组(n=40)患者单独使用益生菌治疗,研究组(n=40)患者使用口服益生菌联合康复新液保留灌肠治疗,均治疗8周,比较2组患者治疗综合疗效及结肠镜下病变活动性评分。结果研究组治疗总有效率为97.5%,明显高于对照组80%,差异具有统计学意义(P<0.05);研究组治疗后的结肠镜病变活动评分明显低于治疗前及对照组,差异具有统计学意义(P<0.05);2组患者均未出现明显严重不良反应。结论益生菌联合康复新液治疗活动期轻中度溃疡性结肠炎的疗效较为显著。

Objective To explore the efficacy and safety of probiotics combined with kangfuxin solution in treatment of mild and moderate active ulcerative colitis.Methods 80 cases of patients with mild and moderate active ulcerative colitis(UC)in Nanyang Central Hospital were divided into two groups according to order of admission,each group had 40 cases.The study group of patients were treated with probiotics combined with kangfuxin solution,while the control group of patients were given probiotics alone.All patients were treated for eight weeks,to compare comprehensive efficacy and colonoscopy disease activity score between two groups of patients. Results The total effective rate of the study group was 97.5%,significantly higher than 80%of the control group,and the difference was statistically significant(P<0.05 );The colonoscopy disease activity score of the study group after treatment was significantly lower than before treatment and of the control group,the difference was statistically significant(P<0.05 );The two groups of patients had no serious adverse reactions.Conclusion Probiotics combined with kangfuxin solution has a significant efficiency in treatment of active mild and moderate ulcerative colitis.