西洛他唑对骨折创伤术后下肢静脉栓塞患者血浆中血小板相关指标的影响

Effects of cilostazol on plasma platelet-related indicators in trauma fractures patients with postoperative venous thrombosis

目的探讨西洛他唑对骨折创伤术后下肢静脉栓塞患者血浆中血小板相关指标的影响。方法选择2012年2月~2013年7月就诊于莱芜市人民医院的104例骨折创伤术后下肢静脉栓塞患者为研究对象,随机分为A、B 2组,每组52例。2组均给予常规护理,A组加用西洛他唑,B组加用阿司匹林选取同期来本院进行体检的50例健康人员作为对照(C组)。分析各组患者血浆中血小板相关指标的变化。结果治疗前A、B 2组血浆中IL-6和IL-8均显著高于C组(P<0.01),治疗后,2组IL-6和IL-8水平均显著降低(P<0.01),但2组组间比较差异无统计学意义。治疗前A、B 2组血浆中CRP、FIB和D-D含量均显著高于C组(P<0.01,P<0.05),治疗后2组CRP、FIB和D-D含量均显著降低(P<0.01,P<0.05),A组CRP较B组含量更低,差异有统计学意义(P<0.05),A组FIB和D-D含量与B组无差异。治疗前A、B两组PDW、PLT、MPV和P-LCR含量均显著高于C组(P<0.01,P<0.05),治疗后2组PDW、PLT、MPV和P-LCR均显著降低(P<0.01,P<0.05),但2组组间比较差异无统计学意义。治疗前A、B 2组血小板活化率均显著高于C组(P<0.01),治疗后,2组血小板活化率均显著降低(P<0.01),但2组间比较差异无统计学意义。结论西洛他唑可通过降低炎性因子的表达、降低D-二聚体和纤维蛋白原的水平以及通过影响血小板相关指标降低血小板的活化,从而发挥抗血栓作用。

Objective To evaluate the effects of cilostazol on plasma platelet-related indicators in trauma fractures patients with postoperative venous thrombosis.Methods 104 cases of trauma fractures patients with postoperative venous thrombosis from February 2012 to July 2013 in Laiwu City People’s Hospital were collected and randomly divided into group A and group group B,each had 52 cases Two groups were given conventional nursing, and group A were added cilostaeol group B were added aspirin.Other 50 cases of current healthy people for medical examination were selected for controls (group C).The effects of cilostazol on plasma platelet-related indicators in each treatment group were analyzed. Result Before treatment,the levels of IL-6 and IL-8 in group A and B were significantly higher than group C(P<0.01),but there is no difference between group A and B.The plasma CRP, FIB and DD in group A and B were significantly decreased than group C(P<0.01,P<0.05).After appropriate treatment,the levels of CRP,FIB and DD in group A and B were significantly reduced than pre-treatment(P<0.01,P<0.05).CRP content in group A was lower than that in group B,the difference was statistically significant(P<0.05 ),FIB and DD in group A showed no differencewith group B.Before treatment,PDW,PLT,MPV and P-LCR in group A and B were significantly higher than group C(P<0.01,P<0.05).After appropriate treatment,the levels of PDW,PLT,MPV and P-LCR in two groups were significantly decreased (P <0.01,P <0.05 ),but there was no difference between two groups.Before treatment,the expression of platelet activation in group A,B were significantly higher than group C(P<0.01),but significantly reduced after appropriate treatment (P<0.01),and the difference between the two groups was not statistically significant.Conclusion Cilostazol could reduce the expression of inflammatory factors,levels of D-dimer and fibrinogen and platelet related indicators by reduced platelet activation,which plays antithrombotic effect.