复方磺胺甲恶唑联合常规雾化治疗支气管结核的临床疗效观察

Clinical efficacy observation of compound sulfamethoxazole combined with conventional atomization in treatment of bronchial tuberculosis

目的探讨和分析复方磺胺甲恶唑联合常规雾化治疗支气管结核临床疗效。方法选取2012年1月~2013年10月在湖北民族学院附属民大医院接受治疗的支气管结核患者190例为研究对象,随机分成2组(n=95),对照组行常规雾化治疗,观察组在行雾化治疗的基础上,同时给予复方磺胺甲恶唑治疗,观察和对比2组患者临床治疗效果及不良反应发发生情况。结果持续治疗4~6个月后,观察组治疗显效率为70.5%、总有效率为89.5%,对照组显效率和总有效率分别为48.4%和76.8%,2组显效率和总有效率对比差异显著,均有统计学差异(P<0.05);在细菌转阴时间指标上,观察组和对照组转阴时间分别为(2.6±0.9)个月和(4.2±1.1)个月,2组对比,差异显著有统计学意义(P<0.05);观察组和对照组不良反应发生率分别为7.4%和11.6%,对比差异不显著。结论应用复方磺胺甲恶唑联合常规雾化治疗支气管结核,疗效快,效果显著,细菌转阴时间短,不良反应低,安全性可靠。

Objective To explore clinical efficacy of compound sulfamethoxazole combined with conventional atomization in treatment of bronchial tuberculosis.Methods 190 cases were selected from January 2012 to October 2013 who diagnosised bronchial tuberculosis treated in minda hospital affiliated of Hubei institute for Nationalities,then the patiens were randomly divided into two groups(n=95 ),the control group underwent conventional spray treatment,the observation group row treatment on the basis of atomization,while giving sulfamethoxazole treatment,observation and comparison of two groups clinical outcomes and adverse reactions. Result After continuous treatment for 4~6 months in the observation group therapy effective rate of 70.5%,total effective rate was 89.5%in the control group significant efficiency and total efficiency of 48.4%and 76.8%,respectively,two groups of significant efficiency and total efficiency,there were significant differences(P<0.05 );bacterial turn negative time indicator on the observation group and the control group were respectively(2.6 ±0.9)months and(4.2 ±1.1)months,there was significant difference(P<0.05);adverse reactions in observation group and control group was 7.4% and 11.6%,respectively,which compared no significant difference.Conclusion Application of compound sulfamethoxazole combined with conventional atomization in treatment of bronchial tuberculosis,has quickly and significantly effect,and bacterial clearance time is short,with low adverse reactions,safety and reliable.