辛伐他汀对2型糖尿病患者尿白蛋白的影响

Effect of Simvastatin on Albuminuria in Type 2 Diabetes M ellitus Patients

目的:应用辛伐他汀治疗2型糖尿病(T2DM)早期肾病,观察患者尿白蛋白,c反应蛋白(C-RP)的变化。方法:2DM早期肾病患者[尿蛋白排泄率(uAER)20-200ug/min]60例,随机分为辛伐他汀治疗组和非辛伐他汀治疗组,各30例,测定血糖,血脂,UAER,CRP等。另选30名健康者和30例单纯T2DM患者作对照.结果:辛伐他汀治疗组和非辛伐他汀治疗组治疗后,血糖,TC,UAER,C-RP均较治疗前下降,治疗后两组间比较差异有显著性(P<0.01)。HDI-C治疗后逐渐升高,与非辛伐他汀组比较差异有显著性(P<0.05)。结论:辛伐他汀可有效降低血脂,CRP的同时,降低UAER水平,使用辛伐他汀进行干预可有效减轻糖尿病肾病患者尿白蛋白。

Objective:To study the effect of simvastatin on albuminuria and C-reactive protein(CRP) in type 2 diabetes mellitus(T2DM) patients.Methods:Sixty early diabetic nephropathy(DN) patients were randomly divided into simvastatin treatment group(SI group) and non-simvatatin treatment group(nonSi group) with 30 cases in each.In addition,30 healthy people and 30 single T2 DM patients were selected for the control.Blood glucose,blood lipid,UAER and CRP were measured.Results:Compared with before treatment,blood glucose,TC,UAER and C-RP in SI and non SI group after treatment were decreased.and there was significant difference between tWO groups(P<0.Ol).After treatment,the level of HDL C was increased gradually.and there was significant difference between two groups(P<0.05).Conclusiofi:Simvastatin can effectively decrease blood lipids,CRP and UAER.The intervention with simvastatin can efficiently alleviate album inuria in DN patients.