心得安在婴幼儿血管瘤治疗方面的研究进展

Research Progress in Infantile Hemangioma Treatment with Propranolol

目的:探讨心得安于婴幼儿血管瘤治疗中的应用价值与安全性。方法:选取血管瘤患儿83例,第1天每次0.5mg/kg(体重),第2天,每次0.75mg/kg(体重),第2天及以后,每次1.0mg/kg(体重),每日早晚8点各1次。观察和比较治疗前后血管瘤的颜色、大小、相关指标、PSV、RI。结果:不同性别、不同发生部位间疗效分布差异无统计学意义(P>0.05);浅表型优良率69.77%优于深部型15.79%、混合型52.38%,治疗持续8个月患者PSV、RI分别为(23.0±5.2)cm/s、(0.85±0.11)优于治疗前(68.3±12.3)cm/s、(0.53±0.14),差异具有统计学意义(P<0.05);未见严重不良反应。结论:心得安治疗婴幼儿血管瘤疗效显著,安全可靠,但疗效受血管瘤类型影响。

Objective:To investigate the application value and safety experience of infantile hemangioma treatment with propranolol. Methods:Selecting 83 children with hemangiomas, 0.5mg/kg(weight) the first day, 0.75mg/kg(weight) the second day, and 1.0mg/kg(weight) every time after the second day with 1 time 8:00 in the morning and afternoon. The color, size, related indicators, PSV and RI of hemangioma were observed and compared. Results:There no statistically significant effect of sex distribution differences among different parts (P>0.05); superficial good rate is 69.77%, which is better than 15.79% of deep type, 52.38% of mixed type. PSV and RI of patients treated for 8 months are(23.0 ± 5.2) cm / s and (0.85 ± 0.11), which are better than (68.3±12.3)cm/s,(0.53±0.14)cm/s before treatment. The difference was statistically significant (P<0.05), with no severe adverse reactions. Conclusion:Propranolol treatment of infantile hemangioma has significant effect, with safe and reliable, but the effects are influenced by the type of hemangioma.