摘要
特发性肺纤维化(IPF)是最难治的慢性纤维化肺部疾病,其死亡率甚至超过许多癌症。尽管过去十年间IPF临床治疗有了很大的进步,但2011年《特发性肺纤维化诊治循证指南》依然宣布到目前为止IPF尚无特效治疗药物。本文综述最近几年国内外有关IPF治疗的研究成果,展望未来IPF治疗药物的研发前景,探索新的治疗靶点及其研究策略的制定。
Idiopathic pulmonary fibrosis(IPF) is the most devastating chronic fibrosing lung disease with a higher mortality rate than many cancers.Although substantial progress has been made in clinical management of IPF in past decade,there is still no proven drug treatment existed for IPF based on '2011 Idiopathic pulmonary fibrosis: evidencebased guidelines for diagnosis and management'.This review describes the updated results of international cooperation in IPF therapy and prospects the development of the treatment drugs for IPF.
出处
《世界临床药物》
CAS
2013年第1期1-6,共6页
World Clinical Drug
关键词
特发性肺纤维化
抗炎
抗纤维化
抗凝血
idiopathic pulmonary fibrosis
anti-inflammatory
antifibrotic
anticoagulant