摘要
目的 研究人胰腺癌组织中增殖细胞核抗原(PCNA)和干扰素调控因子2(IRF2)的表达与临床病理特征的意义及两者间的相互关系.方法 采用免疫组化SP染色法检测60例胰腺癌组织及30例癌旁胰腺组织中PCNA和IRF2的表达情况,并结合临床病理学资料进行分析.结果 免疫组化结果:胰腺癌组织中PCNA和IRF2的阳性表达率分别为83.3％和78.3％,均显著高于癌旁胰腺组织中的表达20.0％和23.3％,差异均有统计学意义(P＜O.001).PCNA的表达与胰腺癌组织患者的年龄、性别、肿瘤部位无关(P＞0.05),与胰腺癌组织的分化程度、TNM分期及淋巴结转移有关(P＜0.05).IRF2的表达与胰腺癌组织患者的年龄、性别、肿瘤部位及淋巴结转移无关(P＞0.05),与胰腺癌组织的分化程度及TNM分期有关(P＜0.05).且PCNA与IRF2的表达呈正相关(γ=0.416,P=0.001).结论 PCNA和IRF2的异常表达与胰腺癌的发生及癌细胞增殖活性有关.
Objective To research the expression levels,clinical significance and the correlation of PCNA and IRF2 in human pancreatic cancer.Methods The expression levels of PCNA and IRF2 in 60 different cases of pancreatic cancer tissues and 30 different cases of para-pancreatic cancer tissues were investigated by Immunohistochemical SP staining and then analyzed through clinicopathological data.Results Immunohistochemical results:the positive expression rates of PCNA and IRF2 in pancreatic cancer tissues were 83.3％ and 78.3％ respectively,which were significantly higher than those in the adjacent pancreatic tissues,of which were 20.0％ and 23.3％ respectively.The differences were statistically significant (P＜0.001).The factors of age,gender,tumor site of patients with pancreatic carcinoma were not statistically significant with the expression of PCNA (P＞0.05),but other factors,such as the differentiation of pancreatic tissue,TNM stage and lymph node metastasis,were statistically significant (P＜O.05).The factors of age,sex,tumor location and lymph node metastasis of pancreatic carcinoma patients were not statistically significant with the expression of PCNA (P＞0.05),but the factors of differentiation of pancreatic tissue and TNM stage were statistically significant (P＜0.05).Moreover,the expression of PCNA and IRF2 was positively correlated (γ =0.416,P=0.001).Conclusion The abnormal expression of PCNA and IRF2 is correlated with occurrence of pancreatic cancer and the cancer cell proliferation activity.
出处
《中国临床实用医学》
2014年第1期-,共3页
China Clinical Practical Medicine
