摘要
随着不孕症人口高龄化,卵巢储备功能降低的患者逐渐增多,如何改善卵巢储备功能降低患者体外受精-胚胎移植(IVF-ET)的治疗结局一直是困扰临床医师的难题。近年临床研究显示,脱氢表雄酮(DHEA)可以改善卵巢储备功能,提高妊娠率,减少染色体非整倍性的发生,降低流产率。而基础研究对雄激素促进卵泡募集与生长发育的作用机制进行了探索。DHEA的这一作用引申出了一种新的观点:随着年龄的增长,卵巢储备功能降低是由卵巢微环境衰老所致,而非卵母细胞的衰老所致,DHEA可能代表着一类能够改善卵巢衰老微环境的新药。但是今后尚需进一步研究为临床应用提供更有力的证据。
More and more patients seem to suffer from the diminished ovarian reserve(DOR) in those infertility populations.How to improve the outcome of IVF-ET in those patients is still a problem.Recently,the first randomized prospective study,and other studies,showed that dehydroepiandrosterone(DHEA)supplementation could improve ovarian reserve,increase pregnancy rates and lower miscarriage rates by reducing aneuploidy.It is necessary to explore the effect of androgens on folliculogenesis and ovulation induction.There was a hypothesis that the diminished ovarian reserve was due to the poor ovarian environments,but not oocytes themselves.DHEA may be a new agent to improve the aging ovarian environments.
出处
《国际生殖健康／计划生育杂志》
CAS
2013年第2期114-117,共4页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金资助项目(81273791)
关键词
去氢表雄酮
受精
体外
胚胎移植
雄激素
生殖技术
辅助
Dehydroepiandrosterone
Fertilization in vitro
Embryo transfer
Androgen
Reproduction techniques,assisted
