丙型肝炎病毒感染对精子和辅助生殖技术结局的作用

Effect of Hepatitis C Virus Infection on Sperm Quality and Outcome of Assisted Reproductive Technology

丙型肝炎病毒(HCV)感染尤其是围生期HCV的感染近来备受关注。男性精液和精子中检出较低浓度的HCV RNA,HCV患者的精液质量包括常规和生物功能参数的下降和HCV患者男性生育功能的明显降低,证实HCV可以影响男性生殖系统并可能造成垂直传播风险。辅助生殖技术(ART)在很好地解决HCV男性患者生育的同时极大地降低了HCV围生期传播,但HCV患者子代的健康仍不容忽视。

HCV infection attracted extensive attention,especially HCV infection in the perinatal period.HCV-RNA can be detected in semen and sperm even at low level.Patients with HCV infection had the impaired sperm parameters,including routine analysis and biofunctional parameters,which suggested that HCV infection impacted male fertility.Those HCV couples can obtain their pregnancies by assisted reproductive technology(ART),and the risk of HCV transmission in perinatal period can be reduced,while health of their descendents can not be ignored.