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雄激素受体翻译后修饰的研究进展 被引量：1

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摘要 雄激素受体(androgen receptor,AR)是一种细胞内的蛋白质,常与雄激素结合形成激素-受体复合物与特异的DNA序列相互作用,调节靶细胞的雄激素特异反应基因表达。近年来多种研究表明,不同的蛋白质翻译后修饰(post-translational modifications,PTMs)影响AR在细胞内的转录、表达及生物活性。同时,在前列腺癌的发生发展中也常伴随着AR的PTMs异常,成为疾病治疗的潜在位点。本文针对近期PTMs对AR影响的报道进行综述。
作者 陈艺轩 伍会健
机构地区 大连理工大学生命科学与技术学院
出处 《生理科学进展》 CAS CSCD 北大核心 2013年第6期442-446,共5页 Progress in Physiological Sciences
基金 国家自然科学基金(31271500) 国家重点基础研究发展计划(973计划)(2011CB504201)资助课题
关键词 雄激素受体 翻译后修饰 前列腺癌
分类号 R737 [医药卫生—肿瘤]
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参考文献15

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二级参考文献61

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生理科学进展
2013年 第6期

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