促红细胞生成素对伴有脊髓高信号的脊髓型颈椎病术后神经功能恢复的临床研究

The effects of Erythropoietin on the postoperative neurologic recovery of cervical spondylotic myelopathy associ- ated with increased signal intensity of spinal cord

目的研究促红细胞生成素(erythropoietin,EPO)对伴有脊髓高信号的脊髓型颈椎病术后神经功能恢复的影响。方法 59例伴有脊髓高信号的脊髓型颈椎病患者按随机数字表分成手术治疗组30例(A组)和手术联合EPO治疗组29例(B组)。B组术后当日给予EPO静脉注射80 IU/kg,每周3次,每周监测HCT,并酌情适当增减EPO用量,使HCT维持在35%左右的理想水平,持续1个月。A组为空白对照组。对两组患者分别于术前,术后1周,术后1月,6月,12月和16月采用JOA评分体系进行神经功能评估。结果术后12个月、16个月时B组神经功能恢复情况优于A组,差异有统计学意义(<0.05)。结论 EPO对于伴有脊髓高信号的脊髓型颈椎病术后神经功能的恢复具有一定疗效。

Objective To evaluate the effect of erythropoietin(EPO) on the recovery of postoperative neurological functions for cervical spondylotic myelopathy associated with increased signal intensityof spinal cord. Methods 59 cases with cervical spondylotic myelopathy associated with increased signal intensity of spinal cord were divided into group A and B: in group A, 30 cases were only treated with surgery, and 29 cases were treated with surgery combined with EPO in group B. Postoperative Group B were given EPO intravenous injection of 80 IU/kg, 3 times a week. weekly monitoring of HCT, and appropriate increase or decrease the dosage of EPO. Keep HCT in about 35% of the ideal level, lasting 1 month. Group A was the control group. Japanese Orthopedic Association(JOA) score system was used to evaluate neurologic function before treatment and at 1 week, 1 month, 6 months, 12 months and 16 months after treatment. Results At 12 months, 16 months, the recovery of postoperative neurological functions of group B was better than group A, the difference was statistically significant( <0.05). Conclusion EPO has a certain effect on the recovery of postoperative neurological functions for cervical spondylotic myelopathy associated with increased signal intensity.