林可霉素治疗肺炎发生不良反应的分析

Analysis on Adverse Reaction Induced by Lincomycin Treatment with Pneumonia

目的:探讨林可霉素治疗肺炎发生的药品不良反应(ADR)的规律和特点。方法:回顾性分析2006年2月-2013年1月笔者所在医院静脉滴注林可霉素治疗肺炎出现不良反应的168例患者的临床资料。结果:林可霉素所致ADR可累及全身各个系统,其中胃肠道系统损害107例(63.7%)和皮疹20例(11.9%);过敏性休克2例(1.2%)、循环系统损害10例(6.0%)、神经系统2例(1.2%)、下肢水肿8例(5.0%)、肝功能损害6例(3.6%)、泌尿系统损害13例(7.7%);男94例(56.0%),女74例(44.0%),ADR可发生于用药后的各个时间段。结论:应重视林可霉素所致过ADR,加强监测,以减少不良反应的发生。

Objective:To explore the rules and characteristics of adverse drug reaction (ADR) of lincomycin in treatment with Pneumonia.Methods:Retrospective analysis of 2006 February-2013 year in January in my hospital intravenous infusion of forests in the clinical data of 168 cases of pneumonia of kanamycintreatment adverse reactions.Results:Clindamycin ADR may be caused by involving the whole body each system,including the gastrointestinal system damage in 107 cases (63.7%) and rash 20 cases (11.9%);Anaphylactic shock in 2 cases (1.2%),circulatory system,10 cases (6.0%),nervous system damage in 2 cases (1.2%),lower extremity edema,8 cases (5.0%),6 cases of liver damage (3.6%),urinary tract damage in 13 (7.7%);94 cases (56.0%),male,74 female patients (44.0%),can happen after the drug (ADR) of each time period.Conclusion:Should pay attention to ADR caused by clindamycin,strengthen monitoring,in order to reduce the occurrence of adverse reactions.