摘要
目的研究胃癌患者血清中血管内皮生长因子-C(VEGF-C)、血管生成素-2(Ang-2)的表达变化及其与胃癌的临床病理特征的关系,探讨VEGF-C与Ang-2在胃癌中的相互关系。方法收集120例胃癌患者及49例健康者(对照组)血清,采用酶联免疫吸附技术(ELISA)检测血清中VEGF-C、Ang-2水平。结果胃癌患者血清中VEGF-C、Ang-2含量较对照组均明显升高,差异具有统计学意义(P<0.05);VEGF-C表达水平升高与胃癌淋巴结转移(P<0.01)、浸润深度(P<0.05)、TNM分期(P<0.01)相关;Ang-2表达水平升高与胃癌淋巴结转移(P<0.01)、浸润深度(P<0.01)、TNM分期(P<0.01)相关;VEGF-C与Ang-2表达成正相关关系(r=0.478,P<0.05)。结论血清中VEGF-C、Ang-2可作为胃癌生物学指标,两者联合可能成为判断胃癌淋巴结转移及预后的重要指标。
Objective To study the relationship between expression changes of serum vascular endothelial growth fac tor-C (VEGF-C) and angiogenin-2 (Ang-2) in patients with gastric cancer and clinicopathological features of gastric cancer,and to investigate the mutual relations of VEGF-C and Ang-2 in gastric cancer.Methods The serum of 120 patients with gastric cancer and 49 cases of health people (control group) were collected and levels of VEGF-C and Ang-2 were detected by enzyme-linked immunosorbent assay (ELISA).Results The levels of VEGF-C and Ang-2 in patients with gastric cancer were markedly higher than that of control group with statistically significant difference ( P< 0.05).Elevated levels of VEGF-C expression was related to and lymph node metastasis of gastric cancer ( P<0.01),depth of invasion (P<0.05) and TNM stage (P<0.01); elevated levels of Ang-2 expression were related to lymph node metastasis of gastric cancer (P <0.01),depth of invasion (P <0.01) and TNM stage (P <0.01); VEGF -C and Ang -2 expression was positively correlated (r=0.478,P<0.05).Conclusion Serum VEGF-C,Ang-2 can be used as biological indicators of gastric cancer,their combination may become important indicators of judging lymph node metastasis and prognosis of gastric cancer.
出处
《中国当代医药》
2013年第24期12-13,16,共3页
China Modern Medicine
关键词
胃癌
血管内皮生长因子-C
血管生成素-2
酶联免疫吸附实验
淋巴结转移
Gastric cancer
Vascular endothelial growth factor-C
Angiopoietin-2
Enzyme-linked immunosorbent assay
Lymph node metastasis
