奥美拉唑联合法莫替丁治疗反流性食管炎的临床分析

Clinical analysis for the effect of omeprazole combined with famotidine in the treatment of reflux esophagitis

目的探讨奥美拉唑联合法莫替丁治疗反流性食管炎的临床疗效及安全性。方法回顾性分析本院2010年1月～2012年12月收治的120例反流性食管炎患者的临床资料,将其分为3组,奥美拉唑组40例,法莫替丁组40例,奥美拉唑联合法莫替丁(联合)组40例,比较3组患者的临床疗效。结果临床治疗情况:联合组的显效率为72.5%,总有效率为97.5%;奥美拉唑组的显效率为42.5%,总有效率为72.5%;法莫替丁组的显效率为20.0%,总有效率为57.5%;联合组的显效率和总有效率显著高于奥美拉唑组和法莫替丁组(P<0.05)。内镜下病变改善情况:联合组的显效率为70.0%,总有效率为97.5%;奥美拉唑组的显效率为45.0%,总有效率为70.0%;法莫替丁组的显效率为17.5%,总有效率为55.0%;联合组的显效率和总有效率显著高于奥美拉唑组和法莫替丁组(P<0.05)。结论奥美拉唑联合法莫替丁治疗反流性食管炎,效果显著,安全性高,目前已成为治疗反流性食管炎的主要方法,对我国治疗反流性食管炎的发展具有重要价值。

Objective To research and evaluate the efficacy of omeprazole combined with famotidine in the treatment of reflux esophagitis.Methods 120 cases of patients with reflux esophagitis in our hospital fromg Jan.2010 to Dec.2012 were retrospectively analyzed.They were randomly divided into 3 groups,40 cases of omeprazole group,40 cases of famotidine group,40 cases of omeprazole combined with famotidine group (joint group),the clinical efficacy of 3 groups were compared.Results The clinical treatment effect:the markedly efficacy rate of joint group was 72.5%,the total effctive rate was 97.5%;Omeprazole group was 42.5% and 72.5% respectively;Famotidine group was 20.0% and 57.5% respectively;the joint group was significantly higher than those of omeprazole group and famotidine group ( P<0.05).The lesions under endoscope to improve the situation:markedly effective rate of the joint group was 70.0%,the total effective rate was 97.5%;Omeprazole group was 45.0% and 70.0% respectively;Famotidine group was 17.5% and 55.0% respectively;the joint group was significantly higher than those of omeprazole group and famotidine group ( P<0.05).Conclusion The clinical effect of omeprazole combined with famotidine in the treatment of reflux esophagitis is good,and the security is better,it has become the main method for the treatment of reflux esophagitis,and promote the development of China′s treatment for reflux esophagitis in the future.