硝苯地平控释片联合缬沙坦治疗原发性高血压的效果观察

Effect observation on nifedipine combined with valsartan in treatment of primary hypertension

目的探讨硝苯地平控释片联合缬沙坦治疗原发性高血压的临床效果。方法选择2011年3月～2012年8月本院收治的90例原发性高血压患者,根据治疗方法分为对照组与治疗组,每组45例,对照组给予硝苯地平控释片治疗,治疗组在对照组的基础上加用缬沙坦治疗,比较两组患者的临床疗效和不良反应。结果对照组患者的总有效率为84.4%,明显低于治疗组的93.3%,两组比较,差异有统计学意义(P<0.05)。对照组患者有1例头痛,2例下肢水肿,不良反应发生率为6.7%;治疗组患者1例头痛,1例恶心,不良反应发生率为4.4%;两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论硝苯地平控释片联合缬沙坦治疗原发性高血压的效果显著。

Objective To explore the clinical effect of nifedipine combined with valsartan in the treatment of primary hypertension.Methods 90 cases of patients with primary hypertension were treated in our hospital from March 2011 to August 2012,they were divided into control group and treatment group according to the treatment,45 cases in each group,the control group were given nifedipine,and the treatment group were given valsartan on the basis of the control group,the clinical curative effect and adverse reaction of patients were compared between two groups.Results The total effective rate was 84.4% in the control group,was significantly less than 93.3% of the treatment group,the difference was significant between the two groups (P<0.05).The control group patients with headache of 1 case,2 cases of lower extremity edema,the incidence of the adverse reaction was 6.7%.The treatment group patients with headache of 1 case,1 case of nausea,the incidence of the adverse reaction was 4.4%.The difference of the incidence of the adverse reactions was significant between the two groups ( P<0.05).Conclusion Nifedipine combined with valsartan therapy of primary hypertension has remarkable effect.