右美托咪定在腹腔镜术后应激反应中的作用

Effect of dexmedetomidine on the stress response after laparoscopic resection

目的探讨右美托咪定在腹腔镜术后应激反应中的作用。方法选择进行腹腔镜手术的50例患者,随机分为对照组25例和实验组25例,在麻醉诱导插管前10min,对照组采用静脉泵注0.9%氯化钠溶液,而实验组则泵注等同剂量的右美托咪定,两组患者泵注的时间均为10min,分别观察与记录两组患者入室、切皮、拔管时的收缩压(SBP)、舒张压(DBP)、心率(HR)。结果在不同时间,与入室时相比,实验组的SBP、DBP、HR无明显变化(P>0.05),而对照组的HR明显加快,SBP、DBP均明显升高(P<0.05)。结论右美托咪定可以有效地减轻患者手术后的应激反应。

Objective To study the effect of Dexmedetomidine on the stress response after laparoscopic resection.Methods 50 cases of patients undergoing laparoscopic surgery were randomly divided into experimental group ( n=25) and control group (n=25).Intravenous injection pump of 0.9% saline solution was adopted 10 min before anesthesia induction of intubation in the control group,while the equivalent dose of dexmedetomidine was adopted in the experimental group.The injection time was 10 min in each group.The systolic blood pressure (SBP),diastolic blood pressure (DBP) and heart rate (HR) at the time points of entering the operating room,skin incision and extubation were respectively observed and recorded in two groups.Results In different time,entering the operating room,compared to the experimental group of SBP,DBP,HR,no significant change (P>0.05),and speeding up in the control group HR,SBP,DBP were significantly increased (P<0.05).Conclusion The stress response of patients after surgery can be effectively relieved by dexmedetomidine.