乙肝病毒携带者母乳喂养的研究

Research on breast feeding in hepatitis B virus carriers

目的探讨乙肝病毒(HBV)携带者母乳喂养的安全性。方法选择HBV携带产妇83例,产前检查静脉血血清乙肝病毒标志物(HBV-M)即乙肝两对半、乙肝病毒基因(HBV-DNA),产后3～5 d检测乳汁中的HBV-DNA。结果 83例HBV-M阳性的产妇中,乳汁检出HBV-M阳性者21例,检出率25.3%。结论产妇乳汁HBV-DNA载量<1×103copies/mL者母乳喂养相对安全,血清HBV-DNA载量≥1×103copies/mL者母乳喂养应谨慎。

Objective To explore the safety of breast feeding in the hepatitis B virus carriers.Methods 390 delivery women with hepatitis B virus(HBV) were selected.HBV antigen-antibody system and HBV-DNA,the serum HBV markers(HBV-M),were detected before the delivery;the HBV-DNA was also detected 3 to 5 days after the delivery.Results Among the 83 delivery women with HBV-M,there were 21 patients with positive result of HBV-M in the detection of breast milk,and the detectable rate was 25.3%.Conclusion When the capacity of HBV-DNA is less than 1×103 copies/mL in the breast milk of delivery women,the breast feeding is relatively safe.Once the capacity of serum HBV-DNA is equal or higher than 1×103 copies/mL,the breast feeding should be carefully considered.