脑卒中急性期血管病与血脂的相关性研究

Relevant research on the correlation between acute phase of stroke-related disease and level of abnormal lipid

目的探讨脑卒中患者急性期的血管病变同血脂异常情况的相关性。方法选取脑卒中(脑梗死、脑出血)发病24～48h患者,采空腹静脉血5mL,以全自动的生化分析仪选酶法、酶联免疫法和比浊法对患者血脂测定后分析,并与对照组比较。结果血脂在脑梗死、脑出血组显着高于对照组,差异有统计学意义(P<0.05),在脑梗死、脑出血组间比较差异无统计学意义(P>0.05);动脉粥样硬化性脑梗死或大血管病组血脂各项显著高于对照组,(P<0.05);腔隙性脑梗死或小血管病组除LDL-C、ApoA、ApoB、Lp(a)外余血脂各项显著高于对照组(P<0.05);动脉粥样硬化性脑梗死与腔隙性脑梗死组间比较仅Tc与Lp(a)差异有统计学意义。结论血脂异常为脑血管病变最重要的因素,通过有效控制血脂,能够预防患者脑卒中发生。

Objective To investigate the correlation between acute phase of stroke-related disease and level of abnormal lipid.Methods Patients with stroke at 24～48 honset were collected the fasting blood 5ml,and the level of serum lipid was measured by automatic biochemical analyzer to enzymatic,enzyme-linked immunosorbent assay and nephelometry analysis.The healthy adults were considered as the control group at the same as the observation group such as age and gender.Results The levels of serum lipid in the cerebral infarction and cerebral hemorrhage group were significantly higher than that in the control group;The level of serum lipid in the atherosclerosis infarction or major disease group was higher than that in the control group;The level of serum lipid in the lacunar infarction or small disease groups was higher than that in the control group except LDL-C,ApoA,ApoB and Lp(a).Conclusion Dyslipidemia in patients with cerebrovascular disease is the most important factor.Stroke can be prevented by effectively controlling the serum lipid.