透明质酸酶佐治难治性结核性脑膜炎的疗效观察

Clinical efficacy of hyaluronidase in the treatment of patients with refractory tuberculous meningitis

目的探讨透明质酸酶佐治难治性结核性脑膜炎的临床疗效。方法选择我院收治的63例结核性脑膜炎患者的临床资料,对照组30例采用常规方法治疗,观察组33例采用透明质酸酶辅助治疗,比较2组临床疗效和相关指标的变化情况。结果观察组总有效率93.94%,明显高于对照组,差异有统计学意义(P<0.05),且观察组发热时间、昏迷时间、住院时间等指标均明显优于对照组,差异有统计学意义(P<0.05)。结论透明质酸酶佐治难治性结核性结膜炎具有明显疗效,有利于促进患者的预后。

Objective To investigate the clinical efficacy of hyaluronidase in the treatment of patients with refractory tuberculous meningitis(TBM).Methods 63 patients with tuberculous meningitis were divided into the control group(30 cases,treated with conventional method)and the observation group(33 cases,treated with hyaluronidase).The clinical effect and related indexes in two groups were compared.Results The total effective rate of observation group was higher than that of control group;The fever,coma,hospitalization time and other indicators in the observation group were significantly better than that in the control group,which had significant difference.Conclusion Hyaluronidase has a significant curative effect on treating the refractory tuberculosis conjunctivitis,which can help to pomote the prognosis of patients with early recovery.