期刊文献+

VEGF与恶性胸膜间皮瘤的研究进展

下载PDF
导出
摘要 恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)起源于胸膜间皮细胞或胸膜下纤维结缔组织,是一种较少的胸膜原发性肿瘤,其恶性程度较高,近年来发病率在全球范围内有逐年增高的趋势.长期接触石棉是主要致病因素,其中云南省大姚县由于特殊的地质结构,石棉的贮藏较为表浅,致石棉纤维易于悬浮于空气中,一直是该病的高发区,病死率高达17.75/10万人[1],成为世界上少有的环境致MPM范例.在组织学上该病分3型:上皮型、纤维肉瘤型及混合型,其中上皮型所占比例最大,较为常见.由于该病临床表现无特异性,故早期诊断较为困难.目前治疗MPM的方法有手术治疗、化疗和放疗,无论是采用单模式治疗(手术、放疗或化疗)还是多模式治疗,疗效均不理想,平均生存期仅为20个月[2].
作者 韩丹
出处 《昆明医科大学学报》 CAS 2013年第7期1-3,11,共4页 Journal of Kunming Medical University
  • 相关文献

参考文献3

二级参考文献114

  • 1胡琼,李维山,郑洪.卵巢黏液性肿瘤caspase-3、caspase-9和Smac的表达及其意义[J].临床与实验病理学杂志,2007,23(2):156-158. 被引量:9
  • 2刘学泽 罗素琼 等.青石棉污染与间皮瘤[J].中华劳动卫生职业病杂志,1998,6:103-105.
  • 3Bottomley A, Coens C, Efficace F, et al. Symptoms and patientreported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTCNCIC08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma.J Clin Oncol,2007; 25: 5770-5776.
  • 4Waller DA, Morritt GN, Forty J. Video-assisted thoracoscopic pleurectomy in the management of malignant pleural effusion.Chest 1995; 107: 1454-1456.
  • 5Soysal O, Karaoglanoglu N, Demiracan S, et al. Pleurectomy/ decortication for palliation in malignant pleural mesothelioma:results of surgery. EurJ Cardiothorac Surg 1997; 11: 210-213.
  • 6Halstead JC, Lim E, Venkateswaran RM, et al. Improved survival with VATS pleurectomy-decortication in advanced malignant mesothelioma. Eur J Surg Oncol 2005; 31: 314-320.
  • 7Nakas A, Martin Ucar AE, Edwards JG, et al. The role of video assisted thoracoscopic pleurectomy/decortication in the therapeutic management of malignant pleural mesothelioma. Eur J Cardiothorac Surg 2008; 33: 83-88.
  • 8Martin-Ucar AE, Edwards JG, Rengajaran A, et al. Palliative surgical debulking in malignant mesothelioma. Predictors of survival and symptom control. EurJ Cardiothorac Surg 2001; 20:1117-1121.
  • 9Dogan AUp Baris YI, Dogan M, et al. Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey. Cancer Res 2006; 66: 5063-5068.
  • 10Lin RT, Takahashi K, Karjalainen A, et al. Ecological association between asbestos-related diseases and historical asbestos consumption: an international analysis. Lancet 2007; 369: 844-849.

共引文献67

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部