神经电生理检查在评价大鼠坐骨神经缺损修复中的作用

An evaluation on repair of sciatic nerve defects in rat using electroneurophysiology examination

目的研究应用神经电生理检查在评价大鼠坐骨神经缺损修复中的作用。方法取大鼠30只,随机分成正常组、自体神经组和硅胶管组,每组10只。自体神经组将剪断的10mm神经缝合于原处,硅胶管组用10mm医用硅胶管桥接神经缺损,正常组不手术。饲养4个月,行神经电生理检查。结果电生理检查坐骨神经动作电位潜伏期(ms)正常组<自体神经组<硅胶管组,动作电位波幅(mV)正常组>自体神经组>硅胶管组,且有显著性差异。结论应用神经电生理检查的动作电位潜伏期和波幅可以评价周围神经损伤的修复情况。

Objective To study the feasibility about evaluation on repair of sciatic nerve defects using electroneurophysiology examination. Methods A series of Sprawn Dawnley rats were randomly divided into 3 groups( 10 rats for each) : auto-nerve graft Group,silione tube Group and normal Group. The sciatic nerve 10mm defects were bridged by auto-nerve graft and silicone tube respectively,while the sciatic nerve of normal rats had no operation. The rats of all groups were breeded for 4 months postoperatively and conducted electroneurophysiology examination. Results Action potential latent period of sciatic nerve was that: normal Group < auto-nerve graft Group < silione tube Group,and action potential amplitude was that: normal Group > auto-nerve graft Group > silione tube Group. Conclusion Using action potential latent period and amplitude of electroneurophysiology examination to evaluate the repair situation of peripheral nerve after its damage is feasible.