联合检测甲胎球蛋白、糖抗原125、糖抗原19-9在鉴别肝脏转移瘤中的意义

The differential diagnosis value of combination detection of serum alpha-fetoprotein,Carbohydrate antigens 125 and 19-9 in liver metastases

目的探讨联合检测甲胎球蛋白(AFP)、糖抗原125(CA125)、糖抗原19-9(CA19-9)在肝细胞癌(HCC)与肝脏转移瘤鉴别诊断中的价值。方法检测93例患者的血清AFP,CA125和CA19-9浓度,其中HCC组45例,肝脏转移瘤组38例,良性肝病组10例。结果①良性肝病组三种标志物均阴性,HCC组AFP阳性率明显高于肝脏转移瘤组,且联合检测AFP、CA125、CA19-9阳性率高达88.9%,明显高于AFP单项检测(P<0.05);②HCC组血清CA19-9和CA125阳性率分别为57.8%和77.8%,联合检测CA19-9、CA125阳性率明显高于肝脏转移瘤组(P<0.05)。结论 AFP仍是诊断肝细胞癌的主要血清学肿瘤标志物,联合检测AFP、CA125、CA19-9可明显提高HCC的敏感性。

Objective To explore the differential diagnosis value of combination detection of serum alpha-fe-toprotein (AFP),Carbohydrate antigens 125 (CA125)and Carbohydrate antigens 19-9(CA19-9)between hepatocel-lular carcinoma (HCC)and liver metastases.Methods The level of serum AFP,CA125 and CA19-9 were detected in 95 patients,including 45 cases of HCC,38 cases of liver metastases,and 10 cases of benign liver disease.Results ① Three markers in patients with benign liver disease were all negative.The positive rate of serum AFP was in-creased significantly (P <0.05)in patients with HCC compared with liver metastases,and the positive rate of joint detection of AFP,CA125 and CA19-9 was 88.9%,which were significantly (P <0.05)higher than AFP detection,② The positive rate of serum CA19-9 and CA125 were 57.8% and 77.8%,respectively,and the positive rate of de-tection of CA19-9 and CA125 significantly (P <0.05)higher in patients with HCC than those of patients with liver metastases.Conclusion AFP is still one of the most important tumor markers in the diagnosis of HCC.Combined de-tection of serum AFP,CA125 and CA19-9 can significantly improve the sensitivity of HCC.