TNF-α、IL-13在溃疡性结肠炎中的表达及临床意义

Expression and significance of TNF-α and IL-13 in ulcerative colitis

目的检测溃疡性结肠炎患者血清中TNF-α、IL-13表达情况,探讨其在溃疡性结肠炎发病过程中所发挥的作用及临床意义。方法收集来源为溃疡性结肠炎患者(UC组)30例及正常人(对照组)30例的外周静脉血,采用ELISA法检测两组血清TNF-α、IL-13的表达情况。结果 UC组血清水平明显高于对照组,差异有统计学意义(P<0.05);UC组患者IL-13的水平低于对照组,差异有统计学意义(P<0.05)。结论 UC组患者血清TNF-α、IL-13水平变化,作为反映溃疡性结肠炎患者结肠炎病症损害程度的灵敏的指标,对于判断溃疡性结肠炎病情变化具有临床意义。

Objective To evaluate the levels of TNF-αand IL-13 in serum from patients with ulcerative colitis( UC) in comparison with those of the healthy people.Methods Serum was obtained from 30 UC subjects and 30 controls.ELISA was performed to evaluate the levels of TNF-αand IL-13 in serum. Results The level of TNF-αwas significantly higher in UC patients than that in controls(P<0.05)and level of IL-13 was significantly lower in UC group compared with the control group(P<0.05).Conclusion TNF-αand IL-13 are closely related in UC and play an important role in the inflammatory progress of this disease.